HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ellis, M J C Articles by Goodbourn, S Search for Related Content PubMed PubMed Citation Articles by Ellis, M J C Articles by Goodbourn, S

In this report we identify novel spliced forms of cyclic AMP (cAMP) response element-binding protein-1 (CREB-1) mRNA. These forms contained an additional 17 nucleotide insert, which we refer to as the β exon, located between exons 4 and 7 of the , and 5 and 7 of the forms of CREB-1 transcript (nomenclature of Ruppert et al. 1992; EMBO Journal 11, 1503-1512). The inclusion of the β exon led to the generation of mRNAs in which the frame of CREB-1 sequences 3' to the exon was shifted such that the encoded proteins terminate after the transactivation domain, but before the target serine for cAMP-dependent protein kinase. The β exon-containing CREB-1 mRNAs were more abundant in tissues that respond poorly to cAMP, suggesting that the generation of βCREB-1 mRNAs may contribute to the down-regulation of CREB-1 activity and cAMP responsiveness.

This article has been cited by other articles:

				N. Sakai, L. M. Tolbert, and R. S. Duman Identification and Functional Analysis of Novel cAMP Response Element Binding Protein Splice Variants Lacking the Basic/Leucine Zipper Domain Mol. Pharmacol., November 1, 1999; 56(5): 917 - 925. [Abstract] [Full Text]

				Y. G. Park, M. Nesterova, S. Agrawal, and Y. S. Cho-Chung Dual Blockade of Cyclic AMP Response Element- (CRE) and AP-1-directed Transcription by CRE-transcription Factor Decoy Oligonucleotide. GENE-SPECIFIC INHIBITION OF TUMOR GROWTH J. Biol. Chem., January 15, 1999; 274(3): 1573 - 1580. [Abstract] [Full Text] [PDF]