HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hubbard, P C Articles by Henderson, I W Search for Related Content PubMed PubMed Citation Articles by Hubbard, P C Articles by Henderson, I W

Introduction: The role of dopamine as a neurotransmitter within the central nervous system is well established. Over the last decade, however, it has become apparent that dopamine plays a number of important regulatory roles outside the confines of the nervous system, most notably in the kidney. Intrarenal dopamine can modify renal haemodynamics, stimulate the release of renin and inhibit the tubular reabsorption of sodium. It is now clear that dopamine is produced extraneurally by the kidney and acts locally on specific dopamine receptors, thus it is acting as a paracrine, or even autocrine, agent at this level. This review assesses the role of intrarenal dopamine in the regulation of sodium excretion by the nephron, and attempts to place it in the context of the actions of other natriuretic and antinatriuretic mechanisms.

Salt intake and renal dopamine production: Increasing dietary salt increases urinary dopamine output in man (Ball et al. 1978,

This article has been cited by other articles:

				D. Jones and R. Bellomo Renal-Dose Dopamine: From Hypothesis to Paradigm to Dogma to Myth and, Finally, Superstition? J Intensive Care Med, July 1, 2005; 20(4): 199 - 211. [Abstract] [PDF]

				Y. A. Debaveye and G. H. Van den Berghe Is There Still a Place for Dopamine in the Modern Intensive Care Unit? Anesth. Analg., February 1, 2004; 98(2): 461 - 468. [Abstract] [Full Text] [PDF]

				C. MISSALE, S. R. NASH, S. W. ROBINSON, M. JABER, and M. G. CARON Dopamine Receptors: From Structure to Function Physiol Rev, January 1, 1998; 78(1): 189 - 225. [Abstract] [Full Text] [PDF]